Mogroside IV-E is primarily used as a natural sweetener due to its intense sweetness, which is significantly higher than that of sucrose. It is extracted from monk fruit and is often incorporated into food and beverage products as a sugar substitute, especially in health-conscious and diabetic-friendly formulations. Its non-caloric nature makes it a popular choice for low-calorie and zero-sugar products. Additionally, it is utilized in traditional medicine for its potential anti-inflammatory and antioxidant properties, contributing to its application in dietary supplements and functional foods aimed at promoting overall health and wellness.