5-(Trifluoromethyl)thiophene-2-sulfonyl chloride
95%
Reagent
Code: #243616
CAS Number
954377-22-1
science Other reagents with same CAS 954377-22-1
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Molecular Information
Weight
250.65 g/mol
Formula
C₅H₂ClF₃O₂S₂
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Registry Numbers
MDL Number
MFCD27934701
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Storage & Handling
Storage
2-8°C, Inert Gas
description Product Description
Used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, particularly in the development of bioactive molecules that require fluorinated aromatic components. Its sulfonyl chloride group readily reacts with amines and alcohols, making it valuable for constructing sulfonamides and sulfonate esters—common motifs in drug design. Frequently employed in medicinal chemistry for modifying thiophene-based scaffolds to enhance metabolic stability and lipophilicity. Also applied in the preparation of functionalized polymers and specialty materials where fluorine substitution improves thermal and oxidative resistance.
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