Enterostatin human is primarily involved in the regulation of food intake, particularly fat consumption. It acts in the brain and adipose tissue to suppress appetite, making it a key peptide in studies related to obesity and metabolic disorders. Research shows it can selectively reduce dietary fat intake without affecting protein or carbohydrate consumption. It also plays a role in energy expenditure and fat metabolism, enhancing fat oxidation in muscle and liver tissues. Due to these effects, enterostatin is being investigated as a potential therapeutic agent for obesity, insulin resistance, and type 2 diabetes. It may also influence gut-brain signaling pathways that control satiety, offering insights into treatments for eating disorders and metabolic syndrome.