2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)-2-oxoacetic acid
95%
Reagent
Code: #58549
CAS Number
73181-56-3
blur_circular Chemical Specifications
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Molecular Information
Weight
272.28 g/mol
Formula
C₁₀H₁₂N₂O₅S
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Registry Numbers
MDL Number
MFCD18074182
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Storage & Handling
Density
1.453±0.06 g/cm3(Predicted)
Storage
2-8°C
description Product Description
This compound, 2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)-2-oxoacetic acid, is a key protected intermediate in the pharmaceutical industry, primarily for the synthesis of third-generation cephalosporin antibiotics such as cefotaxime, ceftriaxone, and related drugs. The Boc group protects the 2-amino functionality on the thiazole ring, while the glyoxylic acid moiety enables coupling to the 7-aminocephalosporin core via amide bond formation. After coupling, the protecting group is removed to yield the active side chain essential for broad-spectrum activity against Gram-negative bacteria.
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