5-(4-Fluoro-3-nitrophenyl)-2H-tetrazole
95%
science Other reagents with same CAS 328244-35-5
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description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor blockers (ARBs), particularly in the production of antihypertensive drugs like valsartan and related derivatives. Its structure enables coupling reactions that form biologically active molecules targeting the renin-angiotensin system. Commonly employed in pharmaceutical research and development for optimizing drug candidates with improved metabolic stability and receptor binding affinity. Also utilized in the preparation of tetrazole-based bioisosteres to replace carboxylic acid groups in drug design, enhancing lipophilicity and oral bioavailability.
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