5-(4-Fluoro-3-nitrophenyl)-2H-tetrazole
95%
Reagent
Code: #173770
CAS Number
328244-35-5
blur_circular Chemical Specifications
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Molecular Information
Weight
209.14 g/mol
Formula
C₇H₄FN₅O₂
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Registry Numbers
MDL Number
MFCD18375293
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor blockers (ARBs), particularly in the production of antihypertensive drugs like valsartan and related derivatives. Its structure enables coupling reactions that form biologically active molecules targeting the renin-angiotensin system. Commonly employed in pharmaceutical research and development for optimizing drug candidates with improved metabolic stability and receptor binding affinity. Also utilized in the preparation of tetrazole-based bioisosteres to replace carboxylic acid groups in drug design, enhancing lipophilicity and oral bioavailability.
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