Benzenesulfonyl fluoride is widely used in organic synthesis as a reagent for introducing the sulfonyl fluoride group into molecules. This functional group is valuable in click chemistry, particularly in sulfur(VI) fluoride exchange (SuFEx) reactions, which are employed for creating stable covalent linkages in materials science, bioconjugation, and drug discovery. It serves as a key intermediate in the development of pharmaceuticals, enabling the synthesis of bioactive compounds with enhanced stability and selectivity. Additionally, it is utilized in the preparation of polymers and advanced materials, where its reactivity allows for the creation of robust and functionalized structures. In proteomics, it is employed as a chemical probe to study protein interactions and modifications due to its ability to selectively react with amino acid residues. Its applications also extend to agrochemical research, where it aids in the design of novel pesticides and herbicides.