Used as a highly reactive electrophilic building block in organic synthesis, particularly in the development of sulfonyl fluoride-based probes for chemical biology. Its reactivity makes it suitable for SuFEx (Sulfur Fluoride Exchange) click chemistry, enabling rapid and selective covalent linkage formation under mild conditions. Commonly employed in the synthesis of covalent inhibitors and labeling agents for proteins, where the sulfonyl fluoride group reacts selectively with nucleophilic amino acid residues such as lysine and tyrosine. Also applied in materials science for constructing robust polymer networks via click reactions. Its stability in aqueous media and high functional group tolerance enhance its utility in diverse reaction environments.