Used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of sulfonyl-containing drugs. Its reactive fluorosulfonyl group enables efficient sulfonylation reactions, making it valuable in medicinal chemistry for constructing biologically active molecules. It is also employed in the preparation of covalent inhibitors, where the fluorosulfonyl moiety acts as an electrophilic warhead that can form stable bonds with nucleophilic residues in target proteins. Additionally, it finds use in chemical biology for probe and labeling applications due to its selective reactivity under controlled conditions.