Used primarily as a highly reactive intermediate in organic synthesis, especially in the preparation of sulfonamide derivatives and fluorinated compounds. Its fluorosulfonyl group readily participates in sulfonylation reactions, making it valuable in pharmaceutical and agrochemical research for building complex molecules. It is also employed in the development of novel materials and functionalized aromatic compounds where introduction of sulfonyl fluoride functionality is required. Due to its reactivity, it enables efficient derivatization in medicinal chemistry, including labeling and bioconjugation applications.