Used as a highly reactive sulfonylating agent in organic synthesis, particularly in the preparation of sulfonamides and sulfonate esters. Its electron-withdrawing trifluoromethyl group enhances electrophilicity, making it effective in peptide modification and protein labeling. Commonly employed in chemical biology for covalent inhibition of serine hydrolases and other enzyme classes due to its ability to react selectively with active-site residues. Also utilized in the development of covalent probes and pharmaceuticals where stable, irreversible binding is desired. Its stability and reactivity profile make it suitable for use in both aqueous and organic solvent systems.