2-Chlorotrityl Chloride Resin is widely used in solid-phase peptide synthesis (SPPS) as a versatile support material. Its primary application is in the attachment of the first amino acid to the resin, providing a stable linkage while allowing for mild cleavage conditions during the final deprotection step. This resin is particularly valued for its ability to facilitate the synthesis of peptide acids, as it enables the release of the peptide without the need for strong acids, thus minimizing side reactions. Additionally, it is suitable for the synthesis of partially protected peptide fragments, which are often used in convergent peptide synthesis strategies. The resin’s compatibility with a wide range of solvents and reagents makes it a popular choice in both research and industrial settings for producing high-purity peptides.