Used as a silylating agent in organic synthesis, particularly for the protection of hydroxyl and amino groups in sensitive molecules. Its bulky structure provides steric shielding, enhancing selectivity in multi-functional compounds.

Commonly applied in the preparation of silicon-based polymers and resins, where it improves thermal stability and moisture resistance. Also employed in surface modification of silica and glass to increase hydrophobicity, making it useful in coatings, adhesives, and microelectronics.

Additionally, used in sample preparation for chromatographic analysis, such as GC or HPLC, to stabilize compounds with -OH or -COOH groups, improving volatility and stability.

Reacts readily with moisture, so it is handled under anhydrous conditions.