Used in research to study the GFRAL (glial cell-derived neurotrophic factor receptor alpha-like) signaling pathway, which plays a key role in metabolic regulation, particularly in mediating the effects of GDF15 on appetite suppression and body weight control. The His Tag allows for easy purification and detection in experimental settings. Commonly applied in protein-protein interaction studies, immunoassays, and structural analysis to develop potential therapeutics for obesity, cancer-related cachexia, and metabolic disorders.