Used in cancer research and immunotherapy development due to its specific binding to EpCAM, a protein overexpressed in many carcinomas. This fusion protein serves as a critical tool in studying tumor cell signaling, adhesion, and immune response modulation. It is employed in assays to evaluate monoclonal antibody efficacy, particularly in detecting or targeting cancer stem cells. Its Fc tag enables easy detection and purification, and supports engagement of immune effector functions in functional studies. Widely applied in flow cytometry, ELISA, and in vivo models for tumor targeting and diagnostic development.