Used in cancer research and drug development, particularly for targeting epidermal growth factor receptor pathways involved in tumor growth. Serves as a recombinant protein for studying receptor-ligand interactions, signal transduction, and efficacy of therapeutic antibodies or small molecule inhibitors. Commonly employed in ELISA, Western blot, and binding assays to evaluate drug candidates. The His tag facilitates easy purification and detection, making it valuable in high-throughput screening and biochemical characterization.