Used in immunotherapy research and development, particularly in targeting epithelial-derived cancers. Plays a key role in cancer biomarker studies due to its high expression on tumor cells, especially carcinomas. Facilitates the development of monoclonal antibodies and CAR-T cell therapies aimed at recognizing and eliminating cancer cells. Commonly employed in ELISA, flow cytometry, and immunohistochemistry assays for detection and quantification. Supports studies in cell adhesion and signaling pathways in epithelial and tumor tissues. The His tag allows for easy purification and detection in recombinant protein applications.