Used in immunological research to study T cell activation and signaling pathways. Serves as a detection tool in immunoassays such as ELISA, flow cytometry, and Western blot due to the Fc tag enabling easy detection and purification. Employed in therapeutic development for immune modulation, particularly in evaluating anti-CD3-based treatments. Facilitates binding studies with other immune molecules or receptors that interact with the CD3 complex. Commonly used in protein-protein interaction assays and as a positive control in experiments involving T cell receptors.