Used as a low-hygroscopic sweetener in food products, especially in dry mix applications like powdered drinks and baked goods. Provides sweetness with reduced moisture absorption, helping to extend shelf life by preventing clumping and maintaining dryness. Also serves as a bulking agent and texture modifier in confectionery and dairy products. Its slow digestion rate and low glycemic index make it suitable for functional foods targeting gradual glucose release and for diabetics.

In pharmaceutical and nutritional supplements, maltulose monohydrate is used as an excipient or additive to aid nutrient absorption and acts as a prebiotic to promote the growth of beneficial gut bacteria, supporting digestion and gastrointestinal health.

In cosmetics, it is employed as a humectant to enhance skin moisture retention due to its water-binding properties, and it is non-irritating, making it safe for skin and lip-contact products.