L-(-)-Fucose is widely used in the pharmaceutical and biotechnology industries as a key building block for synthesizing complex carbohydrates and glycoconjugates. It plays an essential role in the development of therapeutic glycoproteins, where precise glycosylation patterns influence protein stability, solubility, and biological activity. It is also employed in research related to cell signaling, as fucose-containing oligosaccharides are involved in immune responses, inflammation, and pathogen recognition. Additionally, L-(-)-Fucose is used in the production of human milk oligosaccharide (HMO) analogs for infant formula development, supporting gut health and microbial balance in newborns. Its presence in tumor-associated antigens makes it valuable in cancer research and vaccine design targeting abnormal glycosylation in malignant cells.

Furthermore, L-(-)-Fucose finds applications in the cosmetics industry for skin care products, enhancing moisture retention and reinforcing the skin's natural protective barrier. It is also investigated in dietary supplements to promote intestinal health by supporting beneficial microbiota, which may bolster the immune system.