4-(3-Chloro-4-ureidophenoxy)-7-methoxyquinoline-6-carboxamide
98%
Reagent
Code: #156614
CAS Number
417719-51-8
blur_circular Chemical Specifications
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Molecular Information
Weight
386.79 g/mol
Formula
C₁₈H₁₅ClN₄O₄
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Registry Numbers
MDL Number
MFCD32182572
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Physical Properties
Melting Point
>223 °C(dec.)
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Storage & Handling
Storage
Room temperature, seal, dry
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of tyrosine kinase inhibitors, particularly for targeted cancer therapies. Shows potential in inhibiting epidermal growth factor receptor (EGFR) pathways, making it relevant in the development of treatments for non-small cell lung cancer and other solid tumors. Its structure supports high binding affinity to mutant forms of EGFR, including T790M and C797S, which are associated with resistance to earlier generations of inhibitors. Also employed in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of novel anticancer agents.
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