2-Fluoro-5-iodopyrimidine is primarily utilized in the field of organic synthesis and pharmaceutical research. It serves as a key intermediate in the development of various biologically active compounds, particularly in the synthesis of nucleoside analogs. These analogs are often investigated for their potential antiviral and anticancer properties. The presence of both fluorine and iodine atoms in the molecule makes it a versatile building block for further chemical modifications, enabling the creation of complex structures with specific biological activities. Additionally, it is used in cross-coupling reactions, such as Suzuki and Sonogashira couplings, to construct more elaborate molecules for drug discovery and material science applications. Its unique reactivity also makes it valuable in the study of fluorine chemistry, contributing to the development of new synthetic methodologies.