N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
97%
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This compound is primarily utilized in the field of medicinal chemistry as a key intermediate in the synthesis of biologically active molecules. It features a pyrimidine core with a diphenylphosphoryl methyl group at position 5, a 4-fluorophenyl at position 4, an isopropyl at position 6, and an N-methylmethanesulfonamide at position 2. It is often employed in the development of kinase inhibitors, which are crucial in targeted cancer therapies. The diphenylphosphoryl group enhances binding affinity to specific enzyme targets, while the sulfonamide moiety facilitates hydrogen bonding and interactions with biological targets, making it valuable in drug discovery processes. Additionally, structural features such as the fluorophenyl and isopropyl groups contribute to optimizing pharmacokinetic properties, including solubility and metabolic stability. Researchers also explore its application in designing compounds for neurodegenerative diseases due to its ability to modulate protein interactions, as well as potential uses in anti-inflammatory or antimicrobial agents. Its versatility makes it a significant component in the creation of novel therapeutic agents.
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