Esomeprazole magnesium salt is widely used in the treatment of gastrointestinal disorders, particularly those related to excessive stomach acid production. It is commonly prescribed for conditions such as gastroesophageal reflux disease (GERD), where it helps to reduce acid reflux symptoms like heartburn and acid regurgitation. Additionally, it is effective in healing erosive esophagitis, a condition caused by stomach acid damaging the esophagus lining.

This compound is also utilized in the management of peptic ulcers, including those induced by long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). It is often combined with antibiotics in the eradication of Helicobacter pylori, a bacterium responsible for causing certain types of stomach ulcers.

In some cases, it is used to prevent gastric ulcers in patients at risk due to prolonged NSAID use or critical illness. Its ability to inhibit acid secretion makes it a key component in Zollinger-Ellison syndrome treatment, a rare condition characterized by excessive stomach acid production.

Esomeprazole magnesium salt is typically administered orally in the form of delayed-release tablets or capsules, ensuring its effectiveness in targeting acid-producing cells in the stomach.