FMoc-Cit-OMe is widely used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS) methods. It serves as a protected form of citrulline, where the FMoc (fluorenylmethyloxycarbonyl) group acts as a temporary protecting group for the amino group, and the OMe (methyl ester) protects the carboxyl group. This compound is essential for incorporating citrulline residues into peptide chains with high precision. It is especially valuable in research focused on post-translational modifications, as citrullination plays a significant role in various biological processes, including immune response and protein function regulation. Additionally, FMoc-Cit-OMe is utilized in the development of peptides for therapeutic and diagnostic applications, such as studying autoimmune diseases like rheumatoid arthritis, where citrullinated proteins are key biomarkers. Its stability and ease of deprotection make it a reliable choice for peptide chemists.