Nα-Fmoc-D-arginine Hydrochloride is widely used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS). It serves as a protected form of D-arginine, where the Fmoc group acts as a temporary protecting group for the amino group during the assembly of peptide chains. This compound is essential for introducing D-arginine residues into peptides, which is crucial for studying peptide stereochemistry and developing peptides with enhanced stability or biological activity. Its application is particularly significant in the production of therapeutic peptides, peptidomimetics, and research tools for studying protein-protein interactions. The hydrochloride salt form ensures better solubility and handling in organic solvents commonly used in peptide synthesis.