Boc-His-OMe is commonly used in peptide synthesis as a protected form of histidine. The Boc (tert-butyloxycarbonyl) group safeguards the amino group, while the OMe (methyl ester) protects the carboxyl group, allowing selective reactions during peptide chain assembly. It is particularly useful in solid-phase peptide synthesis (SPPS) to ensure precise control over the sequence and structure of peptides. This compound is also employed in the development of biologically active peptides and pharmaceutical research, where histidine plays a critical role in enzyme activity and metal ion binding. Its stability and ease of deprotection make it a valuable intermediate in organic and medicinal chemistry.