Fmoc-2-chloro-L-homophenylalanine is widely used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS). It serves as a protected amino acid derivative, where the Fmoc (fluorenylmethyloxycarbonyl) group acts as a temporary protecting group for the amine functionality. This allows for the sequential addition of amino acids to build peptides with high precision. The chloro substituent on the homophenylalanine side chain can be leveraged for further chemical modifications, making it valuable in the development of peptide-based drugs and bioactive molecules. Its use is critical in creating peptides with specific structural or functional properties, such as those required in medicinal chemistry, biochemical research, and drug discovery. Additionally, it is employed in the synthesis of peptidomimetics and other complex organic molecules where precise control over amino acid incorporation is essential.