Z-Asp(OtBu)-OMe is a protected derivative of aspartic acid, primarily used in peptide synthesis. The Z (benzyloxycarbonyl) group protects the N-terminus, the tert-butyl ester protects the side chain carboxyl group, and the methyl ester protects the C-terminal carboxyl group. This fully protected form enables selective deprotection strategies, allowing precise control in multi-step coupling reactions. It is essential in both solution-phase and solid-phase peptide synthesis for building complex peptides. Additionally, it plays a key role in pharmaceutical development, particularly for peptide-based therapeutics, due to its stability and compatibility with various reagents and conditions. As a valuable intermediate, it supports advanced research in organic and medicinal chemistry.