Z-Aib-OH is widely used in peptide synthesis as a building block to introduce the unnatural amino acid α-aminoisobutyric acid (Aib) into peptide chains. Its incorporation enhances the stability of peptides by promoting helical structures, making it valuable in designing peptides with improved resistance to enzymatic degradation. This property is particularly useful in developing peptide-based drugs and bioactive molecules. Additionally, Z-Aib-OH is employed in research to study protein folding and conformational dynamics, as Aib restricts peptide flexibility, providing insights into secondary structure formation. Its application extends to material science, where it aids in creating peptide-based nanomaterials with specific structural properties.