Fmoc-Phe(2-I)-OH is widely used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS) methods. It serves as a protected amino acid derivative, where the Fmoc (fluorenylmethyloxycarbonyl) group acts as a temporary protecting group for the amine functionality during the peptide chain assembly. The iodine substitution on the phenylalanine side chain introduces a unique reactivity, making it valuable for post-synthetic modifications, such as cross-coupling reactions in the development of peptide-based pharmaceuticals or biomaterials. This compound is especially useful in creating peptides with specific structural or functional properties, such as those required in drug discovery, biochemical research, and the development of targeted therapeutic agents. Its application extends to the synthesis of peptide libraries for high-throughput screening in drug development processes.