Fmoc-Phe(2-F)-OH is primarily used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS). It serves as a protected amino acid derivative, where the Fmoc (fluorenylmethyloxycarbonyl) group protects the amino group during the synthesis process. The 2-fluoro substitution on the phenylalanine side chain can influence the peptide's binding properties and stability, making it useful in the development of peptide-based drugs, enzyme inhibitors, and bioactive peptides. Its application is significant in medicinal chemistry and biochemical research for designing peptides with enhanced specificity and activity.