Epoxomicin is primarily used in biochemical research as a potent and selective proteasome inhibitor. It effectively blocks the chymotrypsin-like activity of the proteasome, making it a valuable tool for studying protein degradation pathways, cellular processes, and the role of the ubiquitin-proteasome system in various diseases. Its application extends to cancer research, where it helps in understanding tumor growth and identifying potential therapeutic targets. Additionally, epoxomicin is utilized in neuroscience studies to explore neurodegenerative disorders linked to protein misfolding and aggregation, such as Alzheimer's and Parkinson's diseases. Its specificity and potency make it a critical compound for advancing knowledge in cell biology and drug development.