Ac-VEID-AMC is widely used in biochemical research as a fluorogenic substrate for studying caspase-6 activity. Caspase-6 is an enzyme involved in apoptosis, the programmed cell death process. Researchers utilize this compound to measure and monitor caspase-6 activity in vitro, helping to understand its role in cellular pathways and disease mechanisms, particularly in neurodegenerative conditions like Alzheimer’s disease. The AMC (7-amino-4-methylcoumarin) moiety, when cleaved by caspase-6, emits fluorescence, allowing for quantitative analysis of enzyme activity. This makes it a valuable tool for drug discovery and screening potential inhibitors of caspase-6, which could have therapeutic applications in treating apoptosis-related disorders.