Used in medicinal chemistry as a key scaffold in the development of boron-containing drugs, particularly in protease inhibitors and enzyme-targeted therapies. Its unique bicyclic structure with a boron atom enables selective interactions with biological targets, enhancing binding affinity and metabolic stability. It is explored in oncology and anti-infective research due to its ability to mimic transition states in enzymatic reactions. Also investigated as a building block in targeted protein degraders and covalent inhibitors where boron facilitates reversible covalent binding. Its application extends to PET imaging agents, leveraging boron isotopes for diagnostic tracing in vivo.