Used in protein purification, particularly in hydrophobic interaction chromatography (HIC). It separates proteins based on their surface hydrophobicity. Ideal for purifying enzymes, antibodies, and other biomolecules that retain activity after exposure to moderate salt concentrations. The octyl group provides a stable hydrophobic ligand, allowing binding under high salt conditions and elution when salt levels decrease. Commonly used in downstream processing of biopharmaceuticals due to its high capacity, chemical stability, and compatibility with cleaning agents. Suitable for both laboratory-scale and industrial applications.