Maackiain is a naturally occurring phytoalexin with notable biological activities, primarily used in agricultural and pharmaceutical research. It exhibits strong antifungal properties, making it valuable in developing plant protection strategies against fungal pathogens, especially in leguminous crops. Its role in inducing plant defense mechanisms supports its application in sustainable farming to reduce reliance on synthetic fungicides. In the pharmaceutical field, maackiain shows promise due to its anti-inflammatory, antioxidant, and anticancer activities. Studies explore its potential in inhibiting tumor cell proliferation and inducing apoptosis in certain cancer lines. Additionally, it has been investigated for its neuroprotective effects, suggesting possible use in treating neurodegenerative conditions. Its ability to modulate key cellular pathways also makes it a candidate for drug development and biochemical studies.