Pristimerin is a natural quinonoid triterpenoid with significant biological activity, making it valuable in pharmaceutical and biomedical research. It exhibits strong anti-cancer properties by inducing apoptosis in various tumor cell lines, including those of breast, prostate, and leukemia cancers, through inhibition of NF-κB and proteasome pathways. Its anti-inflammatory effects are leveraged in studies targeting chronic inflammatory diseases. Additionally, pristimerin shows antimicrobial and antiparasitic activity, particularly against pathogens like *Leishmania* and *Plasmodium*, suggesting potential in treating tropical diseases. Due to its ability to modulate key cellular signaling pathways, it is also used as a research tool in molecular biology to study cell death mechanisms and kinase inhibition.