Oroxylin A is widely studied for its anti-inflammatory and neuroprotective properties, making it a promising candidate in the development of treatments for neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It has been shown to cross the blood-brain barrier effectively, where it modulates key signaling pathways involved in neuronal survival and inflammation. In cancer research, Oroxylin A exhibits anti-tumor activity by inducing apoptosis and inhibiting proliferation in various cancer cell lines, including liver, breast, and colon cancers. It targets multiple oncogenic pathways and enhances the sensitivity of cancer cells to chemotherapy, suggesting its potential as an adjuvant in oncology. Additionally, it possesses antioxidant and hepatoprotective effects, supporting its use in liver protection and metabolic health. Due to its ability to regulate immune responses, Oroxylin A is also explored for managing autoimmune disorders and chronic inflammatory conditions. Its natural origin and low toxicity profile further support its application in functional foods and nutraceuticals aimed at promoting cognitive health and preventing age-related diseases.