Genipin is widely used as a natural cross-linking agent, especially in biomedical applications. It is commonly employed to strengthen hydrogels and scaffolds used in tissue engineering, such as those made from collagen or chitosan, improving their mechanical strength and resistance to degradation. Due to its low cytotoxicity compared to synthetic cross-linkers, genipin is preferred in wound healing materials, drug delivery systems, and cartilage regeneration. It also contributes to the development of biodegradable sutures and contact lens materials. In addition, genipin exhibits anti-inflammatory and antioxidant properties, making it valuable in pharmaceutical formulations and cosmetic products aimed at skin protection and repair. Its ability to form blue pigments when reacting with amino groups is utilized in natural dyeing and as a visual indicator in some diagnostic applications.