Fraxinellone is primarily used in agricultural applications as a natural insecticidal and antifeedant agent. It helps protect crops by deterring insect feeding and disrupting the growth of pest populations, particularly against lepidopteran larvae and aphids. Due to its botanical origin, it is considered an environmentally friendly alternative in integrated pest management programs. It also shows potential in controlling nematodes, making it useful in soil treatment for sustainable farming. Research explores its synergistic effects when combined with other botanical pesticides to enhance efficacy while reducing chemical residues in food and environment.