Tris(trimethylsilyl)phosphite is widely used as a reagent in organic synthesis, particularly in the protection of hydroxyl groups. It is effective in converting alcohols into their corresponding trimethylsilyl ethers, which are stable intermediates that can be easily deprotected later. This compound is also employed in the synthesis of organophosphorus compounds, where it acts as a key building block. Additionally, it finds application in the preparation of phosphite esters, which are useful as antioxidants and stabilizers in polymers and plastics. Its role in facilitating phosphorylation reactions makes it valuable in the development of pharmaceuticals and agrochemicals.