Used primarily as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of anti-inflammatory and antidiabetic agents. Its fluorosulfonyl group enables strong electron-withdrawing properties, making it valuable in constructing sulfonamide and sulfone derivatives through nucleophilic substitution reactions. It is also employed in the preparation of covalent inhibitors due to the reactivity of the sulfonyl fluoride moiety, which can selectively bind to specific amino acid residues in target proteins. Additionally, it finds use in material science for modifying polymer surfaces and enhancing chemical resistance through cross-linking reactions.