Sertaconazole nitrate is widely used in the treatment of fungal infections, particularly those affecting the skin and mucous membranes. It is highly effective against dermatophytes, yeasts, and molds, making it a go-to solution for conditions like athlete's foot, ringworm, and candidiasis. Its antifungal properties work by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes, leading to cell death.

In dermatology, it is commonly formulated as creams, powders, or gels for topical application, providing relief from itching, redness, and scaling associated with fungal infections. Its anti-inflammatory and antipruritic effects further enhance its therapeutic benefits, making it suitable for sensitive skin areas. Additionally, it is used in gynecology to treat vulvovaginal candidiasis, offering rapid symptom relief and high patient compliance due to its low irritation potential. Its broad-spectrum activity and safety profile make it a reliable choice for both acute and chronic fungal infections.