Amiloride hydrochloride is primarily used as a medication to treat high blood pressure and heart failure by helping the body eliminate excess fluid while retaining potassium. It is often prescribed in combination with other diuretics to enhance its effectiveness and reduce the risk of potassium depletion. Additionally, it is utilized in managing conditions like edema caused by heart, liver, or kidney issues. In some cases, it is also applied in research settings to study sodium channels due to its ability to inhibit sodium transport in various tissues. Its role in maintaining electrolyte balance makes it a valuable therapeutic agent in clinical practice.