Used primarily as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of mild to moderate pain, especially in conditions like osteoarthritis and rheumatoid arthritis. It helps reduce inflammation, swelling, stiffness, and joint pain. Diflunisal is also utilized for long-term pain management due to its longer half-life, allowing for less frequent dosing compared to other NSAIDs. It may be prescribed for dental pain, postoperative pain, and musculoskeletal injuries. Additionally, it has been studied for potential use in delaying disease progression in certain amyloidosis types due to its ability to stabilize transthyretin protein.