Used primarily in the treatment of brain tumors, particularly gliomas, due to its ability to cross the blood-brain barrier. It acts as an alkylating agent, interfering with DNA replication in cancer cells, leading to cell death. Also investigated for use in other solid tumors and in palliative care regimens where conventional therapies are less effective. Its lipophilic nature enhances central nervous system penetration, making it valuable in neuro-oncology.