Rilmenidine phosphate is primarily used as an antihypertensive agent, effectively managing high blood pressure by acting on the central nervous system. It stimulates imidazoline receptors in the brain, reducing sympathetic outflow and leading to lowered blood pressure with minimal side effects. Its selective action makes it suitable for patients who may not tolerate other antihypertensive medications well. Additionally, it is often prescribed for long-term management of hypertension due to its once-daily dosing convenience and favorable safety profile. It may also be used in patients with comorbid conditions like diabetes or kidney disease, as it has a neutral metabolic effect.