MIBG is primarily used in nuclear medicine for diagnostic imaging and targeted radiotherapy. It is particularly effective in diagnosing and treating neuroendocrine tumors, such as neuroblastoma and pheochromocytoma, due to its ability to be taken up by cells that produce catecholamines. In diagnostic applications, MIBG is labeled with radioactive iodine (I-123 or I-131) and used in scintigraphy to locate tumors and assess their spread. For therapeutic purposes, MIBG labeled with I-131 delivers targeted radiation to destroy tumor cells while minimizing damage to surrounding healthy tissue. This makes it a valuable tool in both the detection and management of certain cancers.