Flubendazole is primarily used as an anthelmintic agent, effective against a wide range of parasitic worms in veterinary and human medicine. It is commonly applied in the treatment of gastrointestinal nematode infections such as hookworm, roundworm, and whipworm. Its mechanism involves inhibiting microtubule formation in parasites, leading to impaired glucose uptake and eventual parasite death. In veterinary practice, flubendazole is widely used in livestock and poultry to control worm infestations, improving growth performance and overall health. It is also used in aquaculture to treat parasitic infections in fish. Recently, research has explored flubendazole’s potential anticancer properties. Studies indicate it may inhibit tumor cell proliferation and angiogenesis in various cancer types, including breast, prostate, and colon cancers, making it a candidate for repurposing in oncology. Additionally, flubendazole has shown activity against tapeworms and is used in mass drug administration programs in endemic regions to control parasitic diseases. Due to its low solubility and bioavailability, formulation improvements such as micronization and use in suspensions or feed premixes are common to enhance efficacy.