Used primarily in the treatment and prevention of malaria, particularly in regions where Plasmodium falciparum has developed resistance to other antimalarial drugs. It is often administered in combination with other antimalarials, such as artesunate, to enhance efficacy and reduce the risk of drug resistance. Amodiaquine hydrochloride is especially effective in pediatric populations and is widely used in African countries for both uncomplicated malaria and seasonal chemoprevention. Its ability to target liver and blood stages of the parasite contributes to its role in reducing malaria transmission and recurrence. Caution is advised for potential side effects on the liver and blood system with long-term use.